Subtypes of ischemic stroke: A hospital-based stroke registry in Taiwan (SCAN-IV)
Jan 1998Stroke 28(12):2507-12Follow journal
DOI: 10.1161/01.STR.28.12.2507
SourcePubMed
Ping-Keung YipJiann-Shing JengJiann-Shing
JengT. Kevin LeeT. Kevin LeeShow all 7 authorsRong-Chi Chen
Abstract
To better understand the clinical pattern
and further elucidate the risk factors and outcome in different subtypes of
cerebral infarction (CI) of the Chinese in Taiwan, we analyzed the National
Taiwan University Hospital Stroke Registry in 1995 and performed an ethnic
comparison with similar data banks. From the National Taiwan University
Hospital Stroke Registry in 1995, 676 patients (383 men and 293 women; mean
age, 64.9 years; SD, 13.8 years; range, 1 to 98 years) with CI were recruited
for this analysis. CI was classified into five subtypes based on clinical
manifestations, ultrasonographic studies, and neuroimaging findings:
large-artery atherosclerosis, lacunae, cardioembolism, other less common
determined causes, and undetermined cause. Vascular risk factors, extracranial
carotid artery atherosclerosis, and 30-day case-fatality rates were
investigated in each subtype of CI. Of all CI patients, 17%, 29%, 20%, 6%, and
29% were classified as large-artery atherosclerosis, lacunae, cardioembolism,
other determined causes, and undetermined cause subtypes, respectively. The
present results were compared with those from eight similar Western stroke
registries. The relative incidence of lacunar CI in Chinese patients was more
common, but large-artery atherosclerotic CI was less common than in whites.
Hypertension was frequently seen in CI patients, especially in those with
lacunae (85%) and large-artery atherosclerosis (69%). Patients with
cardioembolism had a higher percentage of atrial fibrillation (69%), left ventricular
hypertrophy, and ischemic heart disease than the other patients. Patients with
large-artery atherosclerosis had more vascular risk factors, such as
hypertension, diabetes mellitus, smoking, and carotid stenosis. Cardioembolic
patients had higher case-fatality rates than other CI patients. Of the
cardioembolic patients, 17.3% and 21.8% died within 30 days and during
hospitalization, respectively. The proportion of CI subtypes varied in
different strokes.
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